Division of Nanobiotechnology
Division of Nanobiotechnology is a multidisciplinary research group with a particular focus on the development of novel functional nanomaterials for biomedical applications. With global interest in understanding the biological response of cells in biomaterial research, our group focuses on applying novel functional materials such as 3D scaffolds to develop biomimicking cancer models and glyco-nanoparticles to understand bacterial/viral infections, and nano-carriers for drug delivery applications. The research is also focusing on developing biosensing platforms for ultrasensitive and cost-effective detection of analytes by optical (colorimetric and fluorescence methods), electrochemical, dipstick, and paper-based platforms. The group has expertise in synthesis, functionalization and characterization of nanoparticles (Quantum dots, gold/silver, graphene, TiO2, polymeric, liposome based). This division also houses a state of art facility required for the basic and advanced research, which includes spectroscopy (spectrofluorometer, multimode readers), microscopy, solvo-thermal setup, electrochemical analyser and other basic nanoparticle synthesis apparatus. The faculty projects are financially supported by in-house, national and international agencies. The division is actively looking for researchers from diverse backgrounds (chemistry, physics and biomedical science) to conduct cutting-edge research in the field of nanobiotechnology.
Dr. SUDARSHAN KINI
- DesignationScientist (G-II)
- Email Sudarshan.kini@nitte.edu.in
- Contact No..
- Joining date 20-08-2018
Dr. Sudarshan Kini received his Ph.D. degree in design and development of nanobiomaterials for anticancer drug delivery applications. Later he obtained his postdoctoral experience in Nanodiagnostics from Manipal Academy of Higher Education during 2015-2018. Presently he is working on the development of 3D animal cell culture and Nanosensors.
- Doctor of Philosophy (Nanobiomaterials), Indian Institute of Technology Bombay, 2015
- Master of Science (Biochemistry), Bharathiar University, 2008
Scientist II, Nitte University Centre for Science Education & Research (2018 - Present)
Postdoctoral Research Fellow (Nanodiagnostics), Manipal Academy of Higher Education (2015 - 2018)
Research Associate, Indian Institute of Technology Bombay (Jan 2015 to June 2015)
- Development of Nanobiomaterials and nanodiagnostics for biomedical applications
- Establishment of three-dimensional cell culture to generate biomimetic cancer models.
- Nanobiomaterials and Nanodiagnostics
- Biomimicking Scaffolds
- Cancer Cell Biology
Best Paper award at International conference on Recent Advances in Materials Science and Biophysics at Mangalore, 2018.
Best poster in the International symposium on Nanotechnology and Cancer Theranostics (ISNACT-2015) at IIT Bombay, 2015
GATE qualified with 98.27 percentiles, All India rank 226, score 476.
- In-charge, Institutional Student Innovation Club, NUCSER
- Coordinator, Electoral Literacy Club, NUCSER
- Member, Institutional Ethics Committee, NUCSER
- Member, Academic committee, NUCSER
- Member secretary, Institutional committee against substance abuse, NUCSER
- Member, Youth Red Cross committee, NUCSER
- Member, Institutional Placement & Career Guidance Cell, NUCSER
- Alumni coordinator for NUCSER
- Member, Lab resource committee, NUCSER
- Hostel committee, NUCSER
- Coordinator, Electoral Literacy Club, NUCSER
- Member, Youth Red Cross committee, Nitte DU
Undergraduate
Guidance to research students:
-
General Biochemistry, Radiation Biology, Cancer Biology
Postgraduate Biochemistry, Medical Biochemistry, Nanobiotechnology, Biology and genetics of cancer.
Guidance to research students:
- PhD students: 02 (ongoing)
- PG students: 04
- UG Students: 05
PhD students: 02 (ongoing)
UG Students: 02 (completed)
Journal publications-
Poojari, R., Sawant, A.V., Kini, S., Srivastava, R., Panda, D. (2020) Antihepatoma activity of multifunctional polymeric nanoparticles via inhibition of microtubules and tyrosine kinase. Nanomedicine (London, England) 15(4), 381-396.
Hegde, S., Anchan, B., Kamath, S. U., Kini, S., De, S., Patil, A. (2019) Design and development of ZnO based device for biosensing applications. In A. Asundi, & Q. Kemao (Eds.), Seventh International Conference on Optical and Photonic Engineering, icOPEN 2019 [112052A] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11205). SPIE. doi: 10.1117/12.2551081.
Kini, S., Kulkarni, S.D., Ganiga, V., Nagarakshit, T.K., Chidangil, S. (2019) Dual functionalized, stable and water dispersible CdTe quantum dots: Facile, one-pot aqueous synthesis, optical tuning and energy transfer applications. Materials Research Bulletin 110:57-66.
Kini, S., Ganiga, V., Kulkarni, S.D., Chidangil, S., George, S.D. (2018) Sensitive detection of mercury using the fluorescence resonance energy transfer between CdTe/CdS quantum dots and Rhodamine 6G. Journal of Nanoparticle Research 20:232.
Thakur, R., Kini, S., Kurkalang, S., Banerjee, A., Chatterjee, P., Chanda, A., Chatterjee, A., Panda, D., Mukherjee, A. K. (2016) Mechanism of apoptosis induction in human breast cancer MCF-7 cell by Ruviprase, a small peptide from Daboia russelii russelii venom. Chemico-biological interactions 258, 297-304.
Poojari, R., Kini, S., Srivastava, R., Panda, D. (2016) Intracellular interactions of electrostatically mediated layer-by-layer assembled polyelectrolytes based sorafenib nanoparticles in oral cancer cells. Colloids Surfaces B Biointerfaces 143:131-8.
All Publications: Google Scholar- https://scholar.google.com/citations?user=ixAqu2MAAAAJ&hl=en
As PI:
A novel rapid sensitive fluorescent resonance energy transfer technique for selective detection and quantification of methicillin resistant Staphylococcus aureus, funded by DST-SERB-Early Career Research, 2019-2021 [Budget: 36.14 lakhs]
As Co-PI/Co-I:
Nano-formulation of lutein to improve bioavailability in prevention of Age-Related Macular Degeneration, funded by ICMR, 2019-2021 [Budget: 24.28 lakhs]
Dr. AKSHATH U. S
- DesignationScientist Grade-II
- Email akshath.uchangi@nitte.edu.in
- Contact No..
- Joining date 08-10-2020
Dr. Akshath completed his Ph.D. at CSIR-CFTRI, Mysore, with a specialization in Biosensors and Bio-imaging. His work was focused on nanoparticle-based biosensors to detect food contaminants and toxins using enzymes/aptamers as biorecognition elements. After his Ph.D., he was awarded the prestigious Marie Skłodowska-Curie fellowship (MCIFs) at the University of Leeds, UK. His work was focused on polyvalent glycan-nanoparticles to decipher HIV/Ebola infections using dendritic cell receptors-DCSIGN/R. His research at NUCSER is focused on developing nano-sensors to detect contaminants, bacteria, viruses etc. His research also focuses on glycan-nanoparticles to decipher bacterial/viral infections and inhibition. He has published papers in journals of international repute ex-Journal of American Chemical Society, Biosensors & Bioelectronics, etc.
- Doctor of Philosophy (Life Sciences), CSIR-Central Food Technological Research Institute, Mysore-2018 (Specialization-Nanobiotechnology)
- Master of Science (Biochemistry), University of Mysore, 2008
- Project assistant, CSIR-CFTRI-2010-2014-NPMASS-DRDO Funded project
- PhD-2014-2018, CSIR-CFTRI Mysore
- Marie-Curie Fellow, School of Chemistry, University of Leeds, UK-2018-2020
UG Students: 01 (completed)
- Marie-Curie Individual Fellowship-17/18-University of Leeds, UK
- European Commission-Marie-Curie Fellow (Awarded MC-Individual Fellowship 17/18) School of Chemistry, University of Leeds, UK
- CSIR-CFTRI Annual award-2017 & 2018 for best paper published in Applied Sciences- Biosensors and Bioelectronics, 85 (2016): 240-246, Biosensors & Bioelectronics, 100, 15 February 2018, 201-207
- Honored by Karnataka State Govt on 59th Independence Day on the eve of Designing new methods for Paddy cultivation-2005.
- Member, Consumable committee, NUCSER
- Member, Vigilance committee, NUCSER
- Member, Royal Society of Chemistry
Undergraduate-
Biochemistry
Postgraduate-
Bio-physical principles and Bio-analytical Techniques, Biochemistry
Biochemistry
Postgraduate-
Bio-physical principles and Bio-analytical Techniques, Biochemistry
- Budhadev, D., Poole, E., Nehlmeier, I., Liu, Y., Hooper, J., Kalverda, E., Akshath, U.S., Hondow, N., Turnbull, W.B., Pohlmann, S. and Guo, Y., 2020. Glycan-Gold Nanoparticles as Multifunctional Probes for Multivalent Lectin-Carbohydrate Binding: Implications for Blocking Virus Infection and Nanoparticle Assembly. J. Am. Chem. Soc. 2020, 142, 42, 18022-18034
- Wang, Weili; Kong, Yifei; Jiang, Jun; Tian, Xin; Li, Shuang; Akshath, Uchangi; Tiede, Christian; Hondow, Nicole; Yu, Anchi; Guo, Yuan; Zhou, Dejian, Nanoscale, 2020. Photon induced quantum yield regeneration of cap-exchanged CdSe/CdS quantum rod for ratiometric biosensing and cellular imaging. Nanoscale, 2020, 12, 8647-8655, NC-1
- Sharma, R., Akshath, U.S., Bhatt, P., & Raghavarao, K. S. M. S. (2019). Fluorescent aptaswitch for chloramphenicol detection-Quantification enabled by immobilization of aptamer. Sensors and Actuators B: Chemical, 1 July 2019, 290, 110-117, NC-1
- Akshath, U.S., and Praveena Bhatt., (2017). Supramolecular nano-sniffers for ultrasensitive detection of formaldehyde. Biosensors & Bioelectronics, 100, 15 February 2018, 201-207, NC-2
- Akshath, U.S., and Praveena Bhatt. (2016) Gold nanoparticle synthesis coupled to fluorescence turn-on for sensitive detection of formaldehyde using formaldehyde dehydrogenase"- RSC Advances, 6(60), pp.54777-54784-NC-5
- Akshath, U.S., and Praveena Bhatt. (2016). Tunneling of redox enzymes to design nano-probes for monitoring NAD+ dependent bio-catalytic activity. Biosensors and Bioelectronics, 85 (2016): 240-246, NC-9
- Akshath, U.S., Shubha, L. R., Bhatt, P., & Thakur, M. S. (2014). Quantum dots as optical labels for ultrasensitive detection of polyphenols. Biosensors and Bioelectronics, 57, 317-323-NC-30
- Akshath, U.S., Vinayaka, A. C., & Thakur, M. S. (2012). Quantum dots as nano plug-in's for efficient NADH resonance energy routing. Biosensors and Bioelectronics, 38(1), 411-415-NC-15
Conference publications-09
Conference/Journal publications
Selected Journal publications:
All publication:
https://scholar.google.com/citations?user=-f785t4AAAAJ&hl=en&oi=ao
Conference/Journal workshops: 09
Selected Journal publications:
- Budhadev, D., Poole, E., Nehlmeier, I., Liu, Y., Hooper, J., Kalverda, E., Akshath, U.S., Hondow, N., Turnbull, W.B., Pohlmann, S. and Guo, Y., 2020. Glycan-Gold Nanoparticles as Multifunctional Probes for Multivalent Lectin-Carbohydrate Binding: Implications for Blocking Virus Infection and Nanoparticle Assembly. J. Am. Chem. Soc. 2020, 142, 42, 18022-18034
- Wang, Weili; Kong, Yifei; Jiang, Jun; Tian, Xin; Li, Shuang; Akshath, Uchangi; Tiede, Christian; Hondow, Nicole; Yu, Anchi; Guo, Yuan; Zhou, Dejian, Nanoscale, 2020. Photon induced quantum yield regeneration of cap-exchanged CdSe/CdS quantum rod for ratiometric biosensing and cellular imaging. Nanoscale, 2020, 12, 8647-8655
- Sharma, R., Akshath, U. S., Bhatt, P., & Raghavarao, K. S. M. S. (2019). Fluorescent aptaswitch for chloramphenicol detection-Quantification enabled by immobilization of aptamer. Sensors and Actuators B: Chemical, 1 July 2019, 290, 110-117
- Akshath, U. S., and Praveena Bhatt., (2017). Supramolecular nano-sniffers for ultrasensitive detection of formaldehyde. Biosensors & Bioelectronics, 100, 15 February 2018, 201-207
- Akshath, U. S., and Praveena Bhatt. (2016) Gold nanoparticle synthesis coupled to fluorescence turn-on for sensitive detection of formaldehyde using formaldehyde dehydrogenase"- RSC Advances, 6(60), pp.54777-54784
- Akshath, U. S., and Praveena Bhatt. (2016). Tunneling of redox enzymes to design nano-probes for monitoring NAD+ dependent bio-catalytic activity. Biosensors and Bioelectronics, 85 (2016): 240-246
- Akshath, U. S., Shubha, L. R., Bhatt, P., & Thakur, M. S. (2014). Quantum dots as optical labels for ultrasensitive detection of polyphenols. Biosensors and Bioelectronics,57,317-323
- Akshath, U. S., Vinayaka, A. C., & Thakur, M. S. (2012). Quantum dots as nano plug-in's for efficient NADH resonance energy routing. Biosensors and Bioelectronics,38(1),411-415
All publication:
https://scholar.google.com/citations?user=-f785t4AAAAJ&hl=en&oi=ao
Conference/Journal workshops: 09
Extramural Funding
Intramural Funding
- Polyvalent multifunctional core-shell satellites for ultrasensitive detection of target nucleic acids-a multiplexed approach, Principal Investigator, Funded by UGC-Faculty research promotion scheme, Start-up-Grant, 2021-2024
- Target-induced Core-shell satellite structures: Creating a polyvalent multifunctional platform for multiplexed detection of nucleic acids, Principal Investigator, funded by DST-SERB-Start Up Grant, 2021-2023.
Intramural Funding
- Polyvalent multifunctional core-shell satellites for ultrasensitive detection of target nucleic acids-a multiplexed approach Principal Investigator, funded by NitteDU, 2021-2023.
