Anurag Sharm is working as Assistant Professor at NUCSER, Nitte University. During his Ph.D. he studied the stress response of endosulfan on D. melanogaster, a non-target organism, at sub-organismal as well as organismal level. Further, his studies also highlight the potential of D. melanogaster as an alternative animal model for in-vivo assessment of environmental chemical mediated toxicity, which might have relevance to higher organisms. Later, he joined CNRS-Centre de Biologie du Développement, Toulouse, France as a postdoctoral researcher and worked on deciphering the function of the Drosophila hematopoietic niche to maintain blood cell homeostasis. Presently, he is engaged in the following areas-a) Development of an in vivo Drosophila model to study toxicant/radiation induced hematopoietic perturbations and b) Host-Microbe interaction and environmental toxicants.
Doctor of Philosophy (Cellular and Molecular toxicology), CSIR-IITR Lucknow and Jamia Hamdard, 2012
Master of Science (Biotechnology), Jiwaji University, 2005
Assistant Professor, Nitte Centre for science education and research, Mangaluru (2016 – till date)
Postdoctoral Fellow (Developmental Biology), Centre de Biologie du Développement (CBD), Toulouse, France (2012 - 2016)
Cellular and Molecular toxicology
Cellular immune response
Cellular and molecular stress response
DST-SERB Young scientist start-up grant award, 2017
Japan-Asia Youth Exchange program in Science (SAKURA exchange) awardee, 2018
Member, Lab Resource Committee, NUCSER
Member Secretary, Institutional committee against sexual harassment, NUCSER
Member, Institutional committee against substance abuse, NUCSER
D'Souza, L.C., Mishra, S., Chakraborty, A., Shekher, A., Sharma, A.,* Gupta, .SC.* (2020) Oxidative stress and cancer development: Are non-coding RNAs the missing links? Antioxidants & Redox Signaling [Epub ahead of print].
Sharma A, D'Souza C, Rai V, Gupta SC. (2019) Evaluation of Safety and Efficacy of Nutraceuticals Using Drosophila as an in Vivo Tool. In: Nutraceuticals in Veterinary Medicine. Gupta R, Srivastava A, Lall R. (eds). Springer, Cham. ISBN 978-3-030-04624- 8.
Louradour, I., Sharma, A., Morin-Poulard, I., Letourneau, M., Vincent, A., Vanzo, N., Crozatier, M. (2017). Reactive oxygen species-dependent Toll/NF-κB activation in the Drosophila hematopoietic niche confers resistance to wasp parasitism. Elife 6:e25496. doi: 10.7554/eLife.25496.
Morin-Poulard, I., Sharma, A., Louradour, I., Vanzo, N., Vincent, A., Crozatier, M. (2016). Vascular control of the Drosophila hematopoietic niche: role of Slit/Robo signaling. Nature Communications 7:11634.
Sharma, A., Mishra, M., Shukla, A.K., Kumar, R., Abdin, M.Z., Chowdhuri, D.K. (2012). Organochlorine pesticide, endosulfan induced cellular and organismal response in Drosophila melanogaster. Journal of Hazardous Materials 221-222, 275-287.
Sharma, A., Mishra, M., Ravi Ram, K., Kumar, R., Abdin, M.Z., Chowdhuri, D.K. (2011). Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. Chemosphere 82: 370-376.
Sharma, A., Shukla, A.K., Mishra, M., Chowdhuri, D.K. (2011). Validation and application of Drosophila melanogaster as an in vivo model for the detection of double strand breaks by neutral Comet assay. Mutation Research/ Genetic Toxicology and Environmental Mutagenesis 721: 142-146.
All Publications: Google Scholar-
Decoding the molecular mechanism associated with ionizing radiation induced hematopoietic malignancy using Drosophila model system, funded by ICMR (Recommended), 2020-2022.
Deciphering the molecular mechanisms involved in hematopoietic perturbation induced by environmental chemical(s) using Drosophila as an animal model, funded by DST-SERB, 2017-2020 [Budget: 44.29 lakhs]
Elucidating the host-microbiome association in cadmium and/ nonyphenol exposed Drosophila melanogaster, funded by NitteDU, 2019-2021 [Bugget:1.9 lakhs]
Niche cues for stress hematopoiesis: insights from Drosophila, funded by NitteDU, 2019-2021 [3.0 lakhs]
I am presently working as a Senior Lecturer in NUCSER, have 6 years of teaching experience and am pursuing my Ph.D. in Biological Science stream. In addition, my expertise is in analysis of water quality parameters, microbiological techniques (soil and water), molecular techniques and toxicological studies (acute and chronic toxicity tests). I have been guiding the PG students as a guide and a Co-guide. I am also involved in analyzing external samples of food and water, and also involved in providing training to the personnel form different parts of the country. I have few GenBank submission in my name.