My specific area of research is to understand the role of ribosomes in bone marrow failure syndromes and cancer. Other areas of research include developing non-invasive and alternative DNA-based molecular tools for detection of specific mutations in cancer, developing transgenic zebrafish as cancer models and screening of natural antic-cancer compounds in zebrafish using HTS technology.
Over the past 12 years I have worked on development of many new diagnostic techniques for a bacterial, viral pathogen as well as a parasite affecting humans using my expertise on LAMP technique and characterization (identification and function) of cytokines under different stress/infection. At present my research area and interest focusses on development of rapid molecular detection techniques, development of transgenic zebrafish lines for human diseases, Human /animal parasitology, and Molecular Immunology.
Doctor of Philosophy (Applied Biochemistry and Bioscience), University of Miyazaki, Japan, 2007
Master of Science (Aquaculture), West Bengal University of Animal Sciences, Kolkata, 2003
Molecular detection techniques
The focus of my research is to understand the functioning of disordered and hybrid proteins, with respect to age associated diseases like neurodegeneration and cancer. A parallel interest is to develop amyloid based bio-nanocomposites for diverse applications. During my postdoc at Erasmus Medical Center, Rotterdam and PhD, I gained expertise in protein conformation studies using atomic force microscopy by single molecule imaging and analysis of DNA repair proteins (BRCA2-RAD51), study of polymorphism in self-assembled amyloids (α-synuclein) and functionalization of amyloids with gold nanoparticles (conductive nanowires). I joined NUCSER in 2020.
Doctor of Philosophy (Nanobiophysics), University of Twente, The Netherlands, 2016
Master of Science (Human Genomics), Panjab University, India, 2007
Best debater on "Impact of Nanotechnology on Society", 2014
Immunology foundation fellowship, 2009
EMBO travel award, 2009
UGC-NET lectureship, 2007
Gold medal Panjab University, 2007
Member: Student Welfare Committee, NUCSER
Coordinator, Departmental Journal Club and Work-Discussions, NUCSER
Arshdeep Sidhu, Małgorzata Grosbart, Humberto Sánchez, Bram Verhagen, Nick L L van der Zon, Dejan Ristić, Sarah E van Rossum-Fikkert, Claire Wyman (2020) Conformational flexibility and oligomerization of BRCA2 regions induced by RAD51 interaction. Nucleic Acids Research. (In press) https://doi.org/10.1093/nar/gkaa648 [IF: 11.501]
Sidhu, A*., Vaneyck, J., Blum, C., Segers-Nolten, I., Subramaniam, V. (2018) Polymorph-specific distribution of binding sites determines thioflavin-T fluorescence intensity in Î±-synuclein fibrils. Amyloid 25(3), 189-196.
Sidhu, A., Ristic, D., SÃ¡nchez, H., Wyman, C. (2018) The recombination mediator BRCA2: Architectural plasticity of recombination intermediates revealed by single-molecule imaging (SFM/TIRF). Methods in Enzymology 600: 347-374.
Sidhu, A., Segers-Nolten, I., Raussens, V., Claessens, M. M., Subramaniam, V. (2017). Distinct Mechanisms Determine Î±-Synuclein Fibril Morphology during Growth and Maturation. ACS chemical neuroscience 8(3), 538-547.
Sidhu, A., Segers-Nolten, I., Subramaniam, V. (2016). Conformational Compatibility Is Essential for Heterologous Aggregation of Î±-Synuclein. ACS chemical neuroscience 7(6), 719-727.
Raiss, C.C., Braun, T.S., Konings, I.B., Grabmayr, H., Hassink, G.C., Sidhu, A., le Feber, J., Bausch, A.R., Jansen, C., Subramaniam, V., Claessens, M.M. (2016). Functionally different Î±-synuclein inclusions yield insight into Parkinson's disease pathology. Scientific reports 6, 23116 .
Sidhu, A., Segers-Nolten, I., Subramaniam, V. (2014). Solution conditions define morphological homogeneity of Î±-synuclein fibrils. Biochimica et biophysica acta 1844(12), 2127-2134.
Sidhu, A., Surolia, A., Robertson, A. D., Sundd, M. (2011). A hydrogen bond regulates slow motions in ubiquitin by modulating a Î²-turn flip. Journal of molecular biology 411(5), 1037-1048.
Sidhu, A., Sundd, M. (2009) Protein biotechnology and its applications. Biotechnology applications, ed. C.S.K Mishra.; 213-230.
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