Overview
Research activities in this department are focused on seeking answers for treatment and management of complex human diseases such as cancer and rare bone marrow failure syndromes and hematological disorders. The department is equipped with state-of-the-art research instruments and highly competent faculty with vast experience in the fields of genetics and cancer. Some of the thrust areas include genomics and epigenetics of rare genetic diseases and cancers, the role of small RNAs and noncoding RNAs in cell signaling pathways, the role of ribosomes in human diseases, nucleolar proteins and their role in tumorigenesis, and stem cell deregulation in cancer. The department also focuses on the discovery and development of small molecule anti-cancer drugs through the whole animal small molecule screening or high throughput screening of chemicals using the zebrafish model system. Recently, zebrafish have emerged as a powerful cancer model system because they develop tumors that are histologically similar to human tumors and many human cancer genes are conserved structurally and functionally in zebrafish. In addition, this fish is amenable to pharmacological testing which makes them useful for screening anti- cancer agents. Apart from fish models, the department also houses mice models, which provide exceptional insights into the biology and genetics of human cancer. They are easy to handle and have disease manifestations consistent with humans. In addition to the research activities, the department is dedicated to educating and training the next generation of cancer investigators and human geneticists. The department has been established with a vision of bringing research scientists and clinicians together in order to effectively translate research findings into new ways to detect and treat cancer and genetic disorders.
Thrust Areas
- Disease Modeling in Zebrafish
- Targeting Ribosomes in Cancer
- Small Molecule Screen in Zebrafish
- Non-invasive and Alternative Molecular Tools for Mutation Detection in Cancer
- Genomics of Rare Genetic Disorders
- Bacteria-mediated Cancer Therapy
- In silico Cancer Microarray Analysis
- Validation of Drug Targets by Structural Studies
Faculty
Prof. (Dr.) ANIRBAN CHAKRABORTY
- DesignationDirector, Dean-Faculty of Biological Sciences
- Email anirban@nitte.edu.in
- Contact No..
- Joining date 01-08-2014
My specific area of research is to understand the role of ribosomes in bone marrow failure syndromes and cancer. Other areas of research include developing non-invasive and alternative DNA-based molecular tools for detection of specific mutations in cancer, developing transgenic zebrafish as cancer models and screening of natural antic-cancer compounds in zebrafish using HTS technology.
- Master of Science (Microbiology), University of Agricultural Sciences, Bangalore, 1999
- Doctor of Philosophy (Molecular Biology), United Graduate School of Agricultural Sciences, Kagoshima University, Japan, 2006
- Founder- Consortium of Rare Genetic and Bone Marrow Disorders India Network@NITTEDU (N-CRG.BMD|IN)
- Founder- The Cancer Gene Database@NitteDU(N-TCAG)
- Dean- Faculty of Biological Sciences- Nitte DU (Oct 2020 - To date)
- Director, Centre for Science Education and Research (Oct 2020 - To date)
- Deputy Director, Centre for Science Education and Research (Oct 2017 – Sep 2020)
- Professor, Centre for Science Education and Research (Jan 2017- to date)
- Associate Professor, Centre for Science Education and Research (Aug 2014- Dec 2016)
- Senior Research Associate, Laboratoire de Biologie Moleculaire Eucaryote (LBME), UMR CNRS 5099, Toulouse, France (June 2012- June 2014)
- Postdoctoral Fellow, Frontier Science Research Center, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan (May 2006- March 2012)
- Molecular mechanisms of cancer and inherited bone marrow failure disorders
- Role of ribosomes in cancer
- Nucleolar proteins and their role in tumorigenesis
- Small molecule screening in zebrafish
- Best Researcher of Nitte (Deemed to be University) and Best Researcher of NUCSER by the Nitte (Deemed to be University), 2018
- Early Career Research Award by Dept. of Science and Technology, Science and Engineering Board (DST-SERB), Govt. of India, 2016
- Japan-Asia Youth Exchange program in Science (SAKURA exchange program in science) coordinator, 2015
- The Strategic Priority Research Award by the University of Miyazaki, Faculty of Medicine, Japan, 2011
- Post-doctoral Fellowship for Foreign Researchers by the Japanese Society for Promotion of Science (JSPS), 2006-2008
- Dr. V.G. Jhingran Award for the Best Overseas Indian PhD Thesis Award for the year 2006 by Professional Fisheries Graduates Forum, Mumbai, India
- Monbukagakusho (MEXT) fellowship for PhD by the Government of Japan, 2002-2006
- Senior Research Fellowship by Indian Council of Agricultural Research, India, 2002-2003
- National Eligibility Test (NET) Certificate by ASRB, New Delhi, 1999
- Certificate of Merit by University of Agricultural Sciences, Bangalore for first rank in Masters Degree, 1999
- University Merit Scholarship by University of Agricultural Sciences, Bangalore, during undergraduate studies 1996- 1997
- Member, IQAC, NUCSER
- Member Secretary, Board of Studies, NUCSER
- Member Secretary, Research Advisory Committee, NUCSER
- Member Secretary, Institute Ethics Committee, NUCSER
- Member Secretary, Anti-Ragging Committee, NUCSER
- Member Secretary, Institutional Committee Against Substance Abuse, NUCSER
- Member Secretary, Students Grievance Cell, NUCSER
- In charge, Institutional Public Relations Committee, NUCSER
- Life member, Indian Society of Developmental Biology
- Life member, Molecular Pathology Association of India
- Life member, The Society of Biological Chemists, India
- Life member, Indian Association for Cancer Research
- Life member, Association of Microbiologists of India
Undergraduate-
Cancer Biology; Radiation Biology; Toxicology
Postgraduate-
Medical Genetics; Biology and Genetics of Cancer
Currently enrolled PhD students: 06 Guided PhD students: 02 Guided PG Students: 14
Selected Publications:
- Nanjappa DP, Chakraborty A. Single nucleotide polymorphism in the genomic target affects the recombination efficiency of CRISPR/Cas9-mediated gene editing in zebrafish. Gene Reports (in press)
- Jerome MS, Nanjappa DP, Chakraborty A, Chakrabarty S. Molecular etiology of defective nuclear and mitochondrial ribosome biogenesis: Clinical phenotypes and therapy. Biochimie (in press).
- Bhat S, Mittal B, Nanjappa DP, Chakraborty G, Shetty S, Khanna-Gupta A, Chakraborty A. 2022. Identification of a novel TNFRSF11A gene variant in a rare case of familial osteopetrosis autosomal recessive type 7. Gene Reports 101683
- Prabhakara MA, Nanjappa DP, Kotian A, Krithika K, Chakraborty C, Vittal R, Raj JRM, Deekshit VK, Chakraborty A. 2022. Wild type and cancer-prone zebrafish exhibit distinct gut microbial diversity and show differential anti-inflammatory response upon infection. Journal of Biosciences 47:65
- Babu N, Nanjappa DP, Nazareth S, Arjuna S, Chakraborty A. 2022. PARN knockdown in cell lines results in differential and cell-specific alterations in the expression of cancer-associated mRNAs. Asian Pacific Journal of Cancer Prevention 23 (1): 207-215
- Rathika Damodara Shenoy, Vikram Shetty, Annelies Dheedene, Björn Menten, Dechamma Pandyanda Nanjappa, Gunimala Chakraborty, Patrick Sips, Anne de Paepe, Bert Callewaert, Anirban Chakraborty. 2022. Phenotypic and molecular heterogeneity in Mandibulofacial Dysostoses: A case series from India. The Cleft Palate-Craniofacial Journal 59: 1346-1351
- Audrey D'Cruz, Dechamma Pandyanda Nanjappa, Sahana Maben, Pushparaja Shetty, Anirban Chakraborty. 2021. Non-invasive saliva-based detection of gene mutations in oral cancer patients by Oral Rub and Rinse technique. Asian Pacific Journal of Cancer Prevention22 (10) 3287-3291
- Dechamma Pandyanda Nanjappa, Nishith Babu, Arati Khanna-Gupta, Marie-Françoise O'Donohue, Patrick Sips, Anirban Chakraborty. 2021. Poly (A)-specific ribonuclease (PARN): More than just "mRNA stock clearing". Life Sciences 285:119953
- Bharti Mittal, Dechamma Pandyanda Nanjappa, Gunimala Chakraborty, Anirban Chakraborty, Arati Khanna-Gupta. A patient with Lesch-Nyhan Syndrome presenting with anesthetic challenges: not an exception, but the rule. Gene Reports 24:101289
- Harshitha KP, Dechamma PN, Nishith B, Krithika Kalladka, Shanti Priya Dias, Gunimala Chakraborty, Sudhindra M Rao, Anirban Chakraborty. 2021. TP53 Codon 72 polymorphism and Type 2 Diabetes: A case-control study in South Indian Population. Molecular Biology Reports 48:5093-5097
- Venkataram R, Arjuna S, Hosmane GB, Chakraborty A. 2021. Quantitative analysis of cell-free DNA by droplet digital PCR reveals the presence of EGFR mutations in non-malignant lung pathologies. Monaldi Archives for Chest Disease 91:1748
- Leonard Clinton D'Souza, Shruti Mishra, Anirban Chakraborty, Anusmita Shekher, Anurag Sharma, Subash Chandra Gupta. 2020. Oxidative Stress and Cancer Development: Are non-coding RNAs the missing links? Antioxidants and Redox Signaling 33 (17): 1209-1229
- Srividya Arjuna, Rajesh Venkataram, , Gunimala Chakraborty, Nishith Babu, Audrey D'Cruz, Giridhar Belur Hosmane, Anirban Chakraborty. 2020. Non-invasive detection of EGFR mutations by cell-free loop-mediated isothermal amplification (CF-LAMP). Scientific Reports 10:17559
- Srividya Arjuna, Gunimala Chakraborty, Rajesh Venkataram1, Pandyanda Nanjappa Dechamma, Anirban Chakraborty. 2020. Detection of epidermal growth factor receptor T790M mutation by allele-specific loop mediated isothermal amplification. Journal of Carcinogenesis 19: 3
- Karanth Padyana Anupama, Anirban Chakraborty, Iddya Karunasagar, Indrani Karunasagar Biswajit Maiti. 2019. Loop-mediated isothermal amplification assay as a point-of-care diagnostic tool for Vibrio parahaemolyticus: Recent developments and improvements. Expert Review of Molecular Diagnostics 19: 229-239
- Srividya, Giridhar B.H., Vishwanath S. and Anirban Chakraborty. 2018. Profiling of germline mutations in major hotspot codons of TP53 using PCR-RFLP. Pathology and Oncology Research (in press)
- Shiwangi Dwivedi, Raghav Sharma, Prasanna Kumar Shetty, Anirban Chakraborty. 2018. Association of INS VNTR polymorphisms with polycystic ovary syndrome (PCOS) in South Indian population. Meta Gene 17: 202-205.
- Alexis H Bennett, Marie Francoise O'Donohue, Stacey R Gundry, Aye T Chan, Jeffery Widrick, Isabelle Draper, Anirban Chakraborty, Yi Zhou, Leonard I Zon, Pierre-Emmanuel Gleizes, Alan H Beggs, and Vandana Gupta. 2018. RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes. PLoS Genetics 14(3): e1007226
- Anirban Chakraborty, Tamayo Uechi, Yukari Nakajima, Hanna T. Gazda, Marie-Françoise O'Donohue, Pierre-Emmanuel Gleizes, and Naoya Kenmochi. Cross talk between TP53 and c-Myc in the pathophysiology of Diamond-Blackfan anemia: Evidence from RPL11-deficient in vivo and in vitro models. Biochemical and Biophysical Research Communications 495: 1839-1845.
- Henras A., Plisson-Chastang C., O'Donohue M-F, Anirban Chakraborty, Gleizes P-E. 2014. An overview of pre-ribosomal RNA processing in eukaryotes. Wiley Interdisciplinary Reviews: RNA, 6: 225-242
All Publications:
Google Scholar: https://scholar.google.co.in/citations?user=g-vUFywAAAAJ&hl=en
ResearchGate: www.researchgate.net/profile/Anirban_Chakraborty12
Extramural Funding
- The association of ACE2 and TMPRSS2 gene polymorphisms with susceptibility and severity to COVID-19 in Indian population and validation using zebrafish model system, Principal Investigator, Funded by ICMR, 2022-2025
- Combating cancer through alternative approaches: Investigating the antitumor properties of non-typhoidal Salmonella in transgenic zebrafish cancer models, Principal Investigator, Funded by ICMR, 2021-2024
- Investigating the mechanisms of genetic disorders using the zebrafish model system (GEN-ZEMO), Principal Investigator, Funded by DST-BELSPO, 2018-2021
- RNases and cancer: decoding the role of poly(A)-specific ribonuclease (PARN) in tumorigenesis, funded by DST-SERB, 2017-2020
- Ribosomal defects and craniofacial deformities: A systematic genetic analysis of Treacher Collins syndrome (TCS) and TCS-like cases in India-Genotyping of patients, funded by NitteDU, 2018-2020
- Screening of gene mutations that interferes with response to CCRT in esophageal cancer patients: AS-LAMP assays using cell free DNA, funded by NitteDU, 2019-2021Genetic markers of Tuberculosis among Indo-Tibetan and Indian Population, funded by NitteDU, 2019-2021
- Impact of interaction with children on blood hormonal levels among institutionalized elderly, funded by NitteDU, 2019-2021
- In vitro cytotoxicity evaluation of denture materials used in the fabrication of RPD, funded by NitteDU, 2018-2020
- Effects of Titanium Surfaces on cell viability and cytokine expression in vitro, funded by NitteDU, 2018-2020
- Generation of transgenic zebrafish models for elucidating the molecular mechanisms of Mycobacterium infection, funded by NitteDU, 2018-2020
Intramural Funding
- Non-invasive detection of DNA methylation in lung cancer patients by droplet digital PCR, Principal Investigator, Funded by Nitte (Deemed to be University), 2020-2022
- Genetic testing of non-small cell lung cancers: Development of AS-LAMP assays for detection of EGFR and KRAS mutations, Principal Investigator, Funded by Nitte (Deemed to be University), 2016-2019
- Gene environment interaction in the development of asthma and allergic diseases: A study using Indian population, Principal Investigator, Funded by Nitte (Deemed to be University), 2016-2019
- Co-Founder-Consortium of Rare Genetic and Bone Marrow Disorders India Network@NITTEDU (N-CRG.BMD|IN).
- Coordinator and Team Leader" a three weeks intensive training on cutting edge technologies in biomedical research at University of Miyazaki, Japan, Oct 5 -18, 2015, under Japan-Asia Youth Exchange program in Science (SAKURA exchange program in science) funded by JST, Govt. of Japan
Dr. GUNIMALA CHAKRABORTY
- DesignationHOD & Associate Professor G-II
- Email gunimala@nitte.edu.in
- Contact No..
Over the past 12 years I have worked on development of many new diagnostic techniques for a bacterial, viral pathogen as well as a parasite affecting humans using my expertise on LAMP technique and characterization (identification and function) of cytokines under different stress/infection. At present my research area and interest focusses on development of rapid molecular detection techniques, development of transgenic zebrafish lines for human diseases, Human /animal parasitology, and Molecular Immunology.
Doctor of Philosophy (Applied Biochemistry and Bioscience), University of Miyazaki, Japan, 2007
Master of Science (Aquaculture), West Bengal University of Animal Sciences, Kolkata, 2003
Associate Professor - Grade I, Nitte Centre for Science Education and Research, Mangaluru (2018-till date)
DST women Scientist, Nitte Centre for Science Education and Research, Mangaluru (2015 –2018)
Postdoctoral Fellow, (Infectious Diseases and Parasitology), Faculty of Medicine, University of Miyazaki, Japan (2010-2012).
Postdoctoral Fellow, (Biochemistry and Applied Science), Faculty of Agriculture, University of Miyazaki, Japan (2007 - 2009).
Zebrafish Model system: Transgenesis and disease modelling
Molecular detection techniques
Molecular Genetics
Bioinformatics
Human/animal parasitology
- Best Research Paper Awards 2020: Best Research Paper award of 2020 published from Nitte University Centre for Science Education and Research (NUCSER)
- DST women Scientist Fellow awarded by Department of Science and Technology, Govt. of India, 2015 -2018.
- Postdoctoral Fellow by University of Miyazaki, Department of Infectious Diseases and Parasitology, Faculty of Medicine, Japan,2010-2012
- Postdoctoral Fellow awarded by Japan Society for Promotion of Science, Japan, 2007 - 2009
- Rotary Yoneyama Fellowship for the doctoral studies awarded by Yoneyama Foundation of Japan, April 2005-March 2007
- North East Council (NEC) Fellowship during B.F.Sc. program, awarded by Manipur State Fisheries Department, India ,1997-2001
- Coordinator, Institutional Editorial committee
- Member, Institutional committee against substance abuse
- Member coordinator, Institutional Committee against sexual harassment
- Life Membership, IABMS
- Member, Society of Biological Chemist (India)
Undergraduate
Cell based assays in Biomedical Science, Genetic Engineering, Good Laboratory Practices
Postgraduate
Medical Biotechnology, Application Biotechnology in Food Science, Research Ethics & IPR
Selected Journal publications (last 5 years)-
- Manal Hassan Rajeshwari Vittal, Juliet Mohan Raj · Gunimala Chakraborty. Loop‑mediated isothermal amplification (LAMP): a sensitive molecular tool for detection of Staphylococcus aureus in meat and dairy product. Brazilian Journal of Microbiology. 2022. 53;341-347.
- Rajeshwari Vittal, Juliet Mohan Raj · Gunimala Chakraborty. Rapid detection of Salmonella spp from meat: Loop mediated isothermal amplification (LAMP). Journal of pure and Applied Microbiology.2022;16,
PhD : 02 (ongoing); PG: 05 completed and 03 ongoing UG: 06 completed
- Punja HK, Nanjappa DP, Babu N, Kalladka K, Dias BS, Chakraborty G, Rao SM, Chakraborty A. TP53 codon 72 polymorphism and type 2 diabetes: a case-control study in South Indian population. Molecular Biology Reports. 2021 Jun 28:1-5
- Mittal B, Nanjappa DP, Chakraborty G, Chakraborty A, Khanna-Gupta A. A patient with Lesch-Nyhan Syndrome presenting with anesthetic challenges: not an exception, but the rule. Gene Reports. 2021 Jul 23:101289
- Arjuna S, Venkataram R, Dechamma PN, Chakraborty G, Babu N, D'Cruz A, Hosmane GB, Chakraborty A. Non-invasive detection of EGFR mutations by cell-free loop-mediated isothermal amplification (CF-LAMP). Scientific reports. 2020 Oct 16;10(1):1-7
- Prabhakara Aprathi, Pandyanda Nanjappa Dechamma, Babu Nishith, Kalladka Krithika, Chakraborty Anirban, Chakraborty Gunimala*. Exposure to mosquito repellents causes profound development defects and induces oxidative stress in zebrafish. Journal of Health and Allied Sciences NU, :2020;10:122-127
- Shreya Kunder,Babu Nishith Pandyanda Nanjappa Dechamma, Kalladka Krithika, Chakraborty Gunimala, Chakraborty Anirban*. Evaluation of toxicity and antioxidant property of Cassia fistula stem bark extracts in zebrafish. Journal of Health and Allied Sciences NU:2020; 10:109-115
- Dinesh Deeksha, Pandyanda Nanjappa Dechamma, Babu Nishith, Kalladka Krithika, Chakraborty Gunimala, Chakraborty Anirban*. 2020.Evaluation of toxicity and anti-angiogenic activity of Murraya koenigii leaf extracts in zebrafish. J Health Allied Sci NU:2020; 10:79-85
- Srividya Arjuna, Gunimala Chakraborty, Rajesh Venkataram, Pandyanda Nanjappa Dechamma, Anirban Chakraborty.2020. Detection of epidermal growth factor receptor T790M mutation by allele-specific loop mediated isothermal amplification. Journal of Carcinogenesis
Extramural Funding
- Liquid Biopsy for Lung Cancer: Development of LAMP assays using cell-free DNA for screening of gene mutations that interfere with response to TKIs in patients Principal Investigator, funded by ICMR, Govt. of India, 2020-2023
- The association of ACE2 and TMPRSS2 gene polymorphisms with susceptibility and severity to COVID-19 in Indian population and validation using zebrafish model system Co-Principal Investigator, funded by ICMR (covid Research), Govt. of India,2021-2024
Japan-Asia Youth Exchange program in Science for undergraduates (SAKURA exchange program in science) coordinator, 2018
Japan-Asia Youth Exchange program in Science (SAKURA exchange program in science) awardee, 2016
DR. VIVEK TRIPATHI
- DesignationAssociate Professor - (G-I)
- Email vivek.tripathi@nitte.edu.in
- Contact No..
Dr. Vivek completed his Ph.D. (Molecular & Cell Biology) from Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), Strasbourg Université, France. He has worked as a DBT research associate at National Institute of Immunology (NII), New Delhi India. He did his post-doc at Erasmus University Medical Center (Erasmus MC), Rotterdam, The Netherlands. His research focus includes replication stress mediated DNA damage response and tumorigenesis. Further, he discovered a molecular mechanism underlying the oscillation between sensitivity and resistance to FDA-approved PARP inhibitor drugs for BRCA1- and BRCA2 mutated breast cancer cells with important implications for treatment strategies and patient outcomes. His research interest includes identifying the novel druggable molecular targets associated with SUMOylation/Ubiquitylation cellular pathways and discovering their potential roles in the modulation of replication fork dynamics and genome stability. Thereafter, determine their anticancer efficacy by employing advanced experimental techniques to develop combined therapies which would involve increasing their sensitivity to existing therapeutic drugs for the treatments of cancer patients in the clinics.
Master in Biotechnology, Université Louis Pasteur (ULP), Illkirch, France, 2008
• Doctor of Philosophy (Molecular & Cell Biology), (IGBMC), Strasbourg Université, France, 2012
• Doctor of Philosophy (Molecular & Cell Biology), (IGBMC), Strasbourg Université, France, 2012
Associate Professor G-I, Nitte University Centre for Science Education and Research (NUCSER) (2023-till date)
• Post-doc, Department of Molecular Genetics, Erasmus University Medical Center (Erasmus MC), Rotterdam, The Netherlands (2018- 2022)
• DBT- Research Associate, Department of Genetics, Cell Signalling & Cancer Biology, National Institute of Immunology (NII), New Delhi, India (2013-2018)
Replication Stress and DNA damage
• Fork Stabilization and Genome Stability
• Molecular Biology & Chemoresistance
Member, Academic Committee, NUCSER
Undergraduate: Clinical Genetics
PhD students: 01 (ongoing), UG students: 02 (completed)
Selected Publications
- Dias M P. *, Tripathi V. *, Heijden I V D., Cong K., Manolika E M., Bhin J., Gogola E., Galanos P., Annunziato S., Lieftink C., Sanchez M A., Chakrabarty S., Smith G C M., Ven M V D., Beijersbergen R L., Bartkova J., Rottenberg S., Cantor S., Bartek J., Ray Chaudhuri A. #, Jonkers J. # (2021). Loss of Nuclear DNA ligase III Can Revert PARP Inhibitor Resistance in BRCA1/53BP1 Double- deficient Cells by Exposing ssDNA Gaps. Molecular Cell 81 (22), 4692-4708. [*Equal contribution], [#Co-corresponding author]
- Tripathi V., Kaur E., Kharat S S., Hussain M., Damodaran A P., Kulshrestha S., Sengupta S. (2019). Abrogation of FBW7α-dependent p53 degradation enhances p53's function as a tumor suppressor. Journal of Biological Chemistry, doi:294 (36):13224-13232.
- Mukherjee C., Tripathi V., Manolika E M., Heijink A M., Ricci G., Merzouk S., Boer H R D., Demmers J., van Vugt M A T M., Ray Chaudhuri A. (2019). RIF1 promotes replication fork protection and efficient restart to maintain genome stability. Nature Communications, doi:10.1038/s41467-019-11246-1.
- Priyadarshini R., Hussain M., Attri A., Kaur E., Tripathi V., Priya S., Dhapola P., Saha D., Madhavan V., Chowdhury S., Sengupta S. (2018). BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor. Cell Reports, 24(4):947-961.e947.
- Tripathi V., Agarwal H., Priya S., Batra H., Modi P., Pandey M., Saha D., Raghavan S C., and Sengupta S. (2018). MRN complex-dependent recruitment of ubiquitylated BLM helicase to double-strand breaks negatively regulates DNA repair pathways. Nature Communications, 9(1), 1016.
All Publications:
Google Scholar: https://scholar.google.com/citations?user=tt_F5OgAAAAJ&hl=en
Orcid ID: https://orcid.org/my-orcid?orcid=0000-0002-4453-0105
Dr. RAMA ADIGA
- DesignationAssistant Professor
- Email rama_adiga@nitte.edu.in
- Contact No..
With more than 15 years of experience in research and teaching, she has attended several conferences and been resource person at National and International level. Her latest visit to the U.S.A where she was invited as speaker to present a research paper on Zika virus at the First International Conference on Zika Virus 2017 held at Washington D.C, 2017. Her major research areas include Parasitology with special interest in Malaria in the city of Mangaluru where drug resistance is beginning to appear. She is presently working in the division of Bioinformatics and Computational genomics with increased surveillance and research on various viruses spreading across the globe.
Doctor of Philosophy (Bioscience), Mangalore University, 2012
Master of Science (Biochemistry), Nagpur University, 1988
Diploma Post Graduate Diploma in Advanced Bioinformatics
Bioinformatics Institute of India, Noida, 2005
IBM Advanced Career Education: Web Programming, 2002
IBM Advanced Certificate Course: Oracle 8i, 2002
Assistant Professor, Nitte University Center for Science Education and Research, Mangaluru (2013- till date)
Project Assistant, College of Fisheries, Mangaluru (2006-2013)
Molecular characterization of malarial plasmodium
Malaria and Antimicrobial Resistance
Molecular Biology
Bioinformatics
Sequencing and bioinformatics
Appreciation award from NitteDU for participation in National Integration Camp, 2020
Invited speaker at First International Conference on Zika virus, Washington D.C, U.S.A, 2017
Best Poster Award, Eighth symposium on Diseases in Asian Aquaculture, Mangalore, 2011
Associate Editor, International Journal of Biosensors and Bioelectronics , 2016
Elsevier Outstanding Reviewer Award , 2018
Member, Board of Studies in Biological Sciences (UG and PG), Nitte DU
Member, Lab Vigilance Committee, NUCSER
Program Officer-NSS, NUCSER
Life member, Society for Biological Chemists
Undergraduate-
Clinical Biochemistry, General Biochemistry, Introductory Bioinformatics
Postgraduate-
Bioinformatics and Computational Biology, Medical Biochemistry, Food Chemistry
PhD student :01 (ongoing) • PG student: 03 (completed), 02 ongoing • UG students: 02 (completed), 02 ongoing
Journal publications
- Adiga R (2021). Benchmarking Datasets from Malaria Cytotoxic T-cell Epitopes Using Machine Learning Approach. Avicenna Journal of Medical Biotechnology 13:87-91.
- Rama Adiga, Jyothi Bhatkal (2021). In Silico study of gene expression changes in prostate cancer due to endocrine-disrupting chemicals. Research Journal of Chemistry and Environment.25:1-4
- Adiga, R. (2019). Molecular Docking of Hyrtimomine A-K from marine sponge Hyrtios spp. as anti-cancer target of Phosphoinositide-dependent kinase 1. Asian Journal of Pharmaceutical and Clinical Research 12:130-135.
- Adiga, R. (2019). Emergence of Nipah Virus: A Review. Journal of Biomedical and Pharmaceutical Research 8:48-54
- Adiga, R. (2016). Phylogenetic analysis of the NS5 gene of Zika virus. Journal of Medical Virology 88:1821-1826.
- Adiga, R., Karunasagar, I. (2015) In silico approaches to drug discovery. International Journal of Advanced Research 3:1522-1528.
- Adiga, R., Adiga R. (2015). Bioinformatics based analysis of microarrays in human bipolar disorder. International Journal of Innovative Research in Computer and Communication Engineering 3: 261-266.
Conference publications- 8
PhD student :01 (ongoing)
• PG student: 03 (completed), 02 ongoing
• UG students: 02 (completed), 02 ongoing
Currently guiding Ph.D. student, working on the malaria problem in south-west India
