Overview
This is a multidisciplinary research department with includes the field of biotechnology, applied microbiology, and nanotechnology. The research group is focused on innovative and high-end research emphasizing on the development of molecular diagnostics, efficient utilization of aquatic or other natural resources for the development of effective and alternative therapeutics against agents affecting aquatic animals and human health. Under United Nation’s SDG-14, the department is also focused on research focusing on aquatic animal health management. With global interest in understanding the biological response of cells in biomaterial research, the group also focuses on applying novel functional materials such as 3D scaffolds to develop biomimicking cancer models and glyco-nanoparticles to understand bacterial/viral infections, and nano-carriers for drug delivery applications. The research also focuses on developing biosensing platforms for ultrasensitive and cost-effective detection of analytes by optical (colorimetric and fluorescence methods), electrochemical, dipstick, and paper-based platforms. The group has expertise in the synthesis, functionalization, and characterization of nanoparticles (Quantum dots, gold/silver, graphene, TiO2, polymeric, liposome-based). This department also houses a state of art facility required for basic and advanced research, which includes various modern biotechnological apparatus, aquaculture labs, spectroscopy (spectrofluorometer, multimode readers), microscopy, solvo-thermal setup, electrochemical analyzer, and other basic nanoparticle synthesis apparatus. The faculty projects are financially supported by in-house, national, and international agencies. The department is actively looking for researchers from diverse backgrounds following one health approach (including human, animal, and aquaculture applications) to conduct cutting-edge research in the field of biotechnology.
Thrust Areas
- Microbial Biotechnology and Molecular Diagnostics
- Aquaculture and Marine Biotechnology
- Quorum Sensing and Biocontrol of Pathogens
- Biomimmetic Nanomaterial and Nanodiagnostics
- 3D cultures
- Functional Bio- Nanocomposite
- Nanomedicine and Nanovaccine
Faculty
Dr. BISWAJIT MAITI
- DesignationHOD & Associate Professor G-II
- Email maiti.b@nitte.edu.in
- Joining date 23-08-2013
Following Ph.D., Dr. Biswajit Maiti continued his research career at the College of Fisheries, Mangaluru. Later, he joined NUCSER as Assistant Professor in 2013. He has also worked as a visiting researcher in Food Microbiology at Obihiro University, Japan, during 2015 -2016. From the past decade, he has been working on the development of cutting-edge diagnostic methods for rapid detection microbial pathogens, deciphering outer membrane proteins based-antibiotic resistance of bacterial pathogens, and development of novel vaccines using biotechnological approaches. He has numbers of publications in scientific journals of repute, and book chapters to his credit, received research funds from various external agencies, and guiding students for their Ph.D., and postgraduate research dissertation.
Doctor of Philosophy (Bioscience), Mangalore University, 2012
Master of Science (Microbiology), Jiwaji University, 2006
- Associate Professor – Grade II, Nitte University Centre for science education and research, Mangaluru (2022- to date)
- Associate professor - Grade I, Nitte University Centre for science education and research, Mangaluru (2018- 2022)
- Assistant Professor, Nitte University Centre for science education and research, Mangaluru (2013- 2018)
- Post-doctoral fellow (Food Microbiology), Obihiro University, Hokkaido, Japan (2015 - 2016)
- Post-doctoral research associate, College of Fisheries, Mangaluru (2012 - 2013)
- Development of improved diagnostic methods for the pathogenic bacteria.
- Pathogenesis and membrane-based antibiotic resistance mechanisms of bacteria.
- Role of outer membrane proteins of pathogenic Gram-negative bacteria.
- Aquaculture and Marine Biotechnology.
- Dr. (Mrs.) Gouri Ganguly Memorial Award for Young Scientist, Indian Science Congress, 2018.
- Visiting researcher at Obihiro University, Japan, 2015
- WFCC-MIRCEN-WDCM meeting on Microbial Resources Management and Utilization, IMCAS, Beijing, China, 2014
- Young scientist award, Association of microbiologist of India, 2012
- Short-term research fellowship, Nofima AS, Tromsø, Norway, 2010
- TCDC Expert (laboratory management), FAO-UN, Dhaka, Bangladesh, 2010
- Member, Board of Studies in Biological Sciences (UG & PG), Nitte DU
- Member, Doctoral Studies Cell, Nitte DU
- Member Secretary, Research Advisory Committee, NUCSER
- Member Secretary, Information and Communication Technology Cell, NUCSER
- In-charge, Institutional Lab Vigilance Committee, NUCSER
- Member, Internal Quality Assurance Cell, NUCSER
- Member, Lab Resource Committee, NUCSER
- Member, Institutional Library Committee, NUCSER
- Member, Institutional Committee Against Substance Abuse, NUCSER
- Lifetime member, Indian Association of Biomedical Scientists (IABMS), 2021
- Lifetime member, Association of Food Scientists & Technologists (INDIA) AFST(I), 2021
- Lifetime member, The Society of Biological Chemists (SBC), 2015
- Lifetime member, Indian Science Congress Association (ISCA), 2014
- Lifetime member, The Biotech Research Society (BRSI), 2012
- Lifetime member, Association of Microbiologists of India (AMI), 2008
Undergraduate-
Genetic Engineering and Biotechnology; Fundamentals of Immunology; Bioinformatics; Molecular Biology
Postgraduate-
Medical Biotechnology; Immunology; Cell and Molecular Biology
PhD students: 01 (completed), 05 (ongoing) PG Students: 08 (completed), 03 (ongoing) UG Students: 11 (completed), 02 (ongoing) UG/PG Internship: 03
Selected Journal publications (last 5 years)-
- Prerana, S., Ashwini, P., Anupama, K.P., Prajna, V.S., Prithvisagar, K.S., Nayak, A., Rai, P., Rohit, A., Karunasagar, I., Karunasagar, I., Maiti, B * (2023). Evaluation of reverse transcriptase-polymerase spiral reaction assay for rapid and sensitive detection of severe acute respiratory syndrome coronavirus 2. Clinica Chimica Acta 539: 144-150. [IF: 6.314]
- Deekshit, V.K., Maiti, B., Kumar, B.K., Kotian, A., Pinto, G., Melba G., Bondad-Reantaso, M.G., Karunasagar, I., Karunasagar, I. (2023). Antimicrobial resistance in fish pathogens and alternative risk mitigation strategies. Reviews in Aquaculture 15(1):261-273. [IF: 10.618].
- Akshay, S.D., Anupama, K.P., Deekshit, V.K., Rohit A., Maiti, B * (2022). Effect of sub-minimum inhibitory concentration of ceftriaxone on the expression of outer membrane proteins in Salmonella enterica serovar Typhi. World Journal of Microbiology and Biotechnology 38(11):190. [IF: 4.253]
- Rai, P., Anupama, K.P., Pai, A.P., Prerana, S., Prajna, V.S., Ballamoole, K.K., Maiti, B * (2022). Colorimetric reverse transcriptional loop-mediated isothermal amplification for rapid detection of SARS-CoV-2. International Journal of Infectious Diseases 116: S36. [IF: 12.074]
- Maiti, B *., Anupama, K.P., Rai, P., Karunasagar, I., Karunasagar, I. (2022). Isothermal amplification-based assays for rapid and sensitive detection of SARS-CoV-2: Opportunities and recent developments. Reviews in Medical Virology 32(2): e2274 [IF: 11.043]
- Nayak A, Karunasagar I, Chakraborty A, Maiti B *. (2022) Potential application of bacteriocins for sustainable aquaculture. Reviews in Aquaculture 14(3):1234-1248. [IF: 10.618].
- Anupama KP, Nayak A, Karunasagar I, Karunasagar I, Maiti B *. (2021). Evaluation of loop-mediated isothermal amplification assay along with conventional and real-time PCR assay for sensitive detection of pathogenic Vibrio parahaemolyticus from seafood sample without enrichment. Molecular Biology Reports 48(1):1009-1016. [IF: 2.742]
- Rajeish, M., Mani, M.K., Dechamma, M.M., Bossier, P., Rai, P., Karunasagar, I., Maiti, B *. (2021). Expression profile of heat shock protein 70 in lymphoid organs of Penaeus monodon in response to white spot syndrome virus infection. Aquaculture Research 52(3): 1316-1320. [IF: 2.184]
- Dechamma, MM., Mani, MK., Rajeish, M., Santhosh, KS., Akhila, DS., Maiti, B*., Bossier, P., Karunasagar, I., Karunasagar, I. (2020) Differential expression of akirin gene in black tiger shrimp Penaeus monodon in response to immunostimulant administration and infections with Vibrio harveyi and White spot syndrome virus. Journal of the World Aquaculture Society 51(4):1054-1065. [IF: 3.402]
- Anupama KP, Nayak A, Karunasagar I, Maiti B *. (2020) Rapid visual detection of Vibrio parahaemolyticus in seafood samples by loop-mediated isothermal amplification with hydroxynaphthol blue dye. World Journal of Microbiology and Biotechnology 36(5):76. [IF: 4.253]
- Maiti, B*., Dubey, S., Munang´andu, H.M., Karunasagar, I., Karunasagar, I., Evensen, Ø. (2020) Application of outer membrane protein-based vaccines against major bacterial fish pathogens in India. Frontiers in Immunology 11: 1362. [IF: 8.786]
- Srividya, A., Maiti, B., Chakraborty, A., Chakraborty, G (2019) Loop mediated isothermal amplification: A promising tool for screening genetic mutations. Molecular Diagnosis & Therapy 23(6):723-733. [IF: 4.476]
- Anupama K. P, Chakraborty, A., Karunasagar, I., Karunasagar, I., Maiti., B*. (2019) Loop-mediated isothermal amplification assay as a point-of-care diagnostic tool for Vibrio parahaemolyticus: Recent developments and improvements. Expert Review of Molecular Diagnostics 19(03): 229-239. [IF: 5.670]
- Dubey, S., Maiti, B., Kim, S., Sivadasan, S.M., Kannimuthu, D., Pandey, P.K., Girisha, S.K., Mutoloki, S., Chen, S., Evensen, Ø., Karunasagar, I., Munang´andu, H.M. (2019) Genotypic and phenotypic characterization of Edwardsiella isolates from different fish species and geographic areas in Asia: Implications for vaccine development. Journal of Fish Diseases 42(6):835-850. [IF: 2.58]
- Choudhury, T., Maiti, B., Venugopal, M.N., Karunasagar, I. (2019) Influence of some environmental variables and addition of r-lysozyme on efficacy of Vibrio harveyi phage for therapy. Journal of Biosciences 44(1):8. [IF: 2.795]
- Anupama, K.P., Deeksha, K., Deeksha, A., Karunasagar, I., Karunasagar, I. Maiti, B *. (2019) Comparative performance of TCBS and TSA for the enumeration of trh+ Vibrio parahaemolyticus by direct colony hybridization. Journal of Microbiological Methods 157: 37-42. [IF: 2.622]
List of patents published-
- Maiti B., Nayak, S., Anupama, K.P. Specific primers to detect Acinetobacter baumannii with loop-mediated isothermal amplification assay. Application number: 202241073827; Publication Number: 02/2023; Publication Date: 13/01/2023.
- Maiti, B., Rai, P., Anupama, K.P., Kumar, B.K. Unique primers for rapid detection test for SARS- CoV-2 using loop-mediated isothermal amplification. Application number: 202141030297; Publication Number: 34/2022; Publication Date: 26/08/2022
- Maiti, B., Rai, P., Anupama, K.P. Unique molecular primers to detect SARS- CoV-2 by polymerase spiral reaction assay. Application Number: 202141030214; Publication Number: 36/2022; Publication Date: 09/09/2022.
List of book chapters in edited books: 07
Conference publications: 31
All Publications:
Google scholar: https://scholar.google.co.in/citations?user=1toWRp4AAAAJ&hl=en
Web of Science: https://www.webofscience.com/wos/author/record/J-9120-2019
Scopus: https://www.scopus.com/authid/detail.uri?authorId=34875362800
ORCiD: https://orcid.org/0000-0002-8231-7030
ResearchGate- https://www.researchgate.net/profile/Biswajit-Maiti-3
Extramural Funding
- Deciphering outer membrane protein-based resistance of bacteria to antibiotics and bacteriophage for effective control of multidrug-resistant Acinetobacter baumannii, Principal Investigator, funded by ICMR, 2020-2023
- Biotechnological approaches for prevention and control of fish disease in aquaculture (BIOAQUA), Principal Investigator, funded by DST (Indo-Norway joint research project), 2019-2022
- Rapid and sensitive detection of novel coronavirus (SARS-CoV-2) using isothermal nucleic acid amplification, Principal Investigator, funded by SERB, 2020-2021
- Development of novel methods for the sensitive detection and enumeration of Vibrio parahaemolyticus, Principal Investigator, funded by DBT, 2016-2019
Intramural Funding
- Understanding the role of membrane proteins in the multidrug-resistant clinical strain of Salmonella, Principal Investigator, funded by NitteDU, 2018-2020
Convener, Biotechnology in one health for pre-university college students sponsored by BRSI under the scheme Biotechnology popularization and skill development, 2019-2020.
Dr. RAMYA HARSHA
- DesignationAssistant Professor
- Email ramya@nitte.edu.in
- Contact No..
Dr. Ramya Harsha is an Assistant Professor at NUCSER. She has obtained her Ph.D. degree from Department of Microbiology, University of Mysore in the year 2012. She joined NUCSER in 2013. Her research interests include virulence in bacterial pathogens, quorum sensing and isolation of anti-quorum sensing molecules from phytal sources and attenuation of quorum sensing in bacteria. She has secured second rank in MSc Microbiology from University of Mysore.
- Doctor of Philosophy (Microbiology), University of Mysore, 2012
- Master of Science (Microbiology), University of Mysore, 2000
- Assistant Professor, Nitte Centre for science education and research, Mangaluru (2013 – till date)
- Guest faculty, Dept. of Microbiology, University of Mysore (2006 - 2011)
- Infectious Disease Biology (Bacteriology)
- Virulence mechanisms of pathogens
- Bacterial quorum sensing
- Isolation and identification of anti-quorum sensing molecules
- Microplastics
Sakura Science Fellowship administered by Japan Science & Technology, 2018
- Coordinator IQAC, NUCSER
- Coordinator AISHE, NUCSER
- Coordinator, NUeLearn, NUCSER
- Member secretary, Institutional-Anti-Ragging Committee, NUCSER
- In charge of Hostel committee, NUCSER
- Member, I-CASA, NUCSER
- Member, COVID-19 task force, NUCSER
- Member, Institutional committee for the development of professional competence in teaching, NUCSER
- Life Member, Association of Microbiologists of India
- Member, Society of Biological Chemists, India
Undergraduate-
Basic Microbiology, Medical Microbiology
Postgraduate-
General Microbiology, Medical Microbiology, Agricultural Microbiology
Selected Journal Publications
- Scholtz, V., Vanková, E., Kašparová, P., Premanath, R., Karunasagar, I., Julák, J. (2021) Non-thermal plasma treatment of ESKAPE pathogens: a review. Frontiers in Microbiology 12:737635
- Prathiksha, P.A., Sarika, S., Dechamma, P.N., Jainey, P.J., Rajesh, K., Anirban, C., Sarojini, B.S., Premanath, R. (2021) Isolation and identification of quorum sensing antagonist from Cinnamomum verum leaves against Pseudomonas aeruginosa. Life Sciences 267:118878
- Sarika, S., Prathiksha, P.A., Premanath, R. (2021) Modulation of quorum sensing-associated virulence in bacteria: carbohydrate as a key factor. Archives of Microbiology 203: 1881-1890
- Prathiksha, P. A., Shraddha S., Caroline D'Souza, Premanath, R. (2021) Increased expression of genes involved in biofilm formation in a multidrug‑resistant environmental Pseudomonas aeruginosa isolate. Journal of Datta Meghe Institute of Medical Sciences University. 2021; 10.4103/jdmimsu.jdmimsu_286_20
- Prathiksha, P.A., Sarika, S., Gururaj, M.P., Premanath, R. (2019) Evaluation of anti-quorum sensing activity of indigenous dietary plants against Pseudomonas aeruginosa. European Journal of Integrative Medicine 30: 100931
- Sarika, S., Prathiksha, P.A., Akash, S.K., Premanath, R. (2019) Biofilm Forming Abilities of Microorganisms Associated with Diabetic Wound Infection: A Study from a Tertiary Care Hospital. Biomedical & Pharmacology Journal 12(2): 669-676
- Sarika, S., Anupama, K. P., Prathiksha, P.A., Akash, S.K., Maiti, B., Karunasgar, I., Karunasagar, I., Premanath, R. (2019) Diabetic foot ulcer caused by Vibrio parahaemolyticus - Two case reports. Clinical Microbiology Newsletter 41: 101-102
- Prathiksha, P.A., Prasad, R., Venkatesh, T., Suresh, P.S., Premanath, R. (2019) Increased virulence in Pseudomonas aeruginosa at pathological glucose levels. Infectious diseases 51: 153-156
- Prathiksha, P.A., Juliet, M.R., Karunasagar, I., Premanath R. (2018) Environmental and clinical Pseudomonas aeruginosa isolates with pooled presence of exo S, exo U, exo T and exo Y genes. Journal of Pure and Applied Microbiology 12: 1119-1124
- Premanath, R., Lakshmidevi, N. (2015) Antidiabetic and Antioxidant potential of Andrographis paniculata Nees. leaf ethanol extract in streptozotocin induced diabetic rats. Journal of Applied Pharmaceutical Science 5: 69-76
PhD students: 01 (completed), 03 (ongoing) PG Students: 10 (completed), 02 (ongoing) UG students: 03 (completed), 02 (ongoing)
Selected Journal Publications:
- Scholtz, V., Vanková, E., Kašparová, P., Premanath, R., Karunasagar, I., Julák, J. (2021) Non-thermal plasma treatment of ESKAPE pathogens: a review. Frontiers in Microbiology 12:737635
- Prathiksha, P.A., Sarika, S., Dechamma, P.N., Jainey, P.J., Rajesh, K., Anirban, C., Sarojini, B.S., Premanath, R. (2021) Isolation and identification of quorum sensing antagonist from Cinnamomum verum leaves against Pseudomonas aeruginosa. Life Sciences 267:118878.
- Sarika, S., Prathiksha, P.A., Premanath, R. (2021) Modulation of quorum sensing-associated virulence in bacteria: carbohydrate as a key factor. Archives of Microbiology 203: 1881-1890.
- Prathiksha, P. A., Shraddha S., Caroline D'Souza, Premanath, R. (2021) Increased expression of genes involved in biofilm formation in a multidrug‑resistant environmental Pseudomonas aeruginosa isolate. Journal of Datta Meghe Institute of Medical Sciences University. 2021; 10.4103/jdmimsu.jdmimsu_286_20.
- Prathiksha, P.A., Sarika, S., Gururaj, M.P., Premanath, R. (2019) Evaluation of anti-quorum sensing activity of indigenous dietary plants against Pseudomonas aeruginosa. European Journal of Integrative Medicine 30: 100931.
- Sarika, S., Prathiksha, P.A., Akash, S.K., Premanath, R. (2019) Biofilm Forming Abilities of Microorganisms Associated with Diabetic Wound Infection: A Study from a Tertiary Care Hospital. Biomedical & Pharmacology Journal 12(2): 669-676.
- Sarika, S., Anupama, K. P., Prathiksha, P.A., Akash, S.K., Maiti, B., Karunasgar, I., Karunasagar, I., Premanath, R. (2019) Diabetic foot ulcer caused by Vibrio parahaemolyticus - Two case reports. Clinical Microbiology Newsletter 41: 101-102.
- Prathiksha, P.A., Prasad, R., Venkatesh, T., Suresh, P.S., Premanath, R. (2019) Increased virulence in Pseudomonas aeruginosa at pathological glucose levels. Infectious diseases 51: 153-156.
- Prathiksha, P.A., Juliet, M.R., Karunasagar, I., Premanath R. (2018) Environmental and clinical Pseudomonas aeruginosa isolates with pooled presence of exo S, exo U, exo T and exo Y genes. Journal of Pure and Applied Microbiology 12: 1119-1124.
- Premanath, R., Lakshmidevi, N. (2015) Antidiabetic and Antioxidant potential of Andrographis paniculata Nees. leaf ethanol extract in streptozotocin induced diabetic rats. Journal of Applied Pharmaceutical Science 5: 69-76.
Research projects
Extramural Funding
- Attenuation of Pseudomonas aeruginosa virulence by dietary phytochemicals from vegetables as quorum sensing inhibitors, Principal Investigator, funded by DBT, 2013-2017.
Intramural Funding
- Biofilm formation and virulence gene expression in environmental and clinical isolates of Pseudomonas aeruginosa, Principal Investigator, funded by Nitte DU, 2016-2018
- Effect of carbohydrate on quorum sensing mediated pathogenicity in Pseudomonas aeruginosa, Principal Investigator, funded by Nitte DU
- Use of phytochemicals in inhibiting quorum sensing mediated biofilm formation in Acinetobacter baumanii, Principal Investigator, funded by Nitte DU
- Biocontrol of biofilm forming bacteria isolated from diabetic ulcers using phages, Co-principal Investigator, funded by Nitte DU
Dr. SUDARSHAN KINI
- DesignationScientist (G-II)
- Email Sudarshan.kini@nitte.edu.in
- Contact No..
Dr. Sudarshan Kini is a Bionanotechnologist who obtained Ph.D. (Nanotechnology) from the Indian Institute of Technology Bombay and has Post-Doctoral experience from Manipal University. His research areas are the fabrication of biomaterial scaffolds for the 3D culturing of cancer cells and Pseudomonas biofilms. He is also working on developing quantum dot-based fluorescent nanobiosensors to detect MRSA (Methicillin-resistant Staphylococcus aureus).
- Doctor of Philosophy (Nanobiomaterials), Indian Institute of Technology Bombay, 2015
- Master of Science (Biochemistry), Bharathiar University, 2008
Scientist II, Nitte University Centre for Science Education & Research (2018 - Present)
Postdoctoral Research Fellow (Nanodiagnostics), Manipal Academy of Higher Education (2015 - 2018)
Research Associate, Indian Institute of Technology Bombay (Jan 2015 to June 2015)
- Development of Nanobiomaterials and nanodiagnostics for biomedical applications
- Establishment of three-dimensional cell culture to generate biomimetic cancer models.
- Nanobiomaterials and Nanodiagnostics
- Biomimicking Scaffolds
- Cancer Cell Biology
Best Paper award at International conference on Recent Advances in Materials Science and Biophysics at Mangalore, 2018.
Best poster in the International symposium on Nanotechnology and Cancer Theranostics (ISNACT-2015) at IIT Bombay, 2015
GATE qualified with 98.27 percentiles, All India rank 226, score 476.
- In-charge, Institutional Student Innovation Club, NUCSER
- Coordinator, Electoral Literacy Club, NUCSER
- Member, Institutional Ethics Committee, NUCSER
- Member, Academic committee, NUCSER
- Member secretary, Institutional committee against substance abuse, NUCSER
- Member, Youth Red Cross committee, NUCSER
- Member, Institutional Placement & Career Guidance Cell, NUCSER
- Alumni coordinator for NUCSER
- Member, Lab resource committee, NUCSER
- Hostel committee, NUCSER
- Coordinator, Electoral Literacy Club, NUCSER
- Member, Youth Red Cross committee, Nitte DU
Undergraduate
General Biochemistry, Radiation Biology, Cancer Biology
Postgraduate
Biochemistry, Medical Biochemistry, Nanobiotechnology, Biology and Genetics of Cancer
Ph.D scholars: 4 Postgraduate students: 08 Undergraduate students: 09
Journal publications:
- Paithankar JG, Kushalan S, Hegde S, Kini S* and Sharma A*. Systematic toxicity assessment of CdTe quantum dots in Drosophila melanogaster. Chemosphere 2022;295:133836. https://doi.org/10.1016/j.chemosphere.2022.133836. (IF .7)
- Badekila, AK., Rai P, and Kini, S*. Identification and evaluation of an appropriate housekeeping gene for real time gene profiling of hepatocellular carcinoma cells cultured in three dimensional scaffold. Mol Biol Rep 49, 797-804 (2022). https://doi.org/10.1007/s11033-021-06830-y (IF 2.36)
- Badekila AK, Kini S*, Jaiswal AK, Fabrication techniques of biomimetic scaffolds in three‐dimensional cell culture: A review, J Cell Physiol. 2020:236:741-762. https://doi.org/10.1002/jcp.29935. (Q2, IF 6.5)
- Kini S, Kulkarni SD, Ganiga V, Nagarakshit TK, Chidangil S. Dual functionalized, stable and water dispersible CdTe quantum dots: Facile, one-pot aqueous synthesis, optical tuning and energy transfer applications. Mater Res Bull 2019;110:57-66. doi:10.1016/j.materresbull.2018.10.013. (Q2, IF.4.6)
- Kini S, Ganiga V, Kulkarni SD, Chidangil S, George SD. Sensitive detection of mercury using the fluorescence resonance energy transfer between CdTe/CdS quantum dots and Rhodamine 6G. J Nanoparticle Res 2018;232. doi:10.1007/s11051-018-4320-5. (Q3, IF.2.25)
- Kini S, Bahadur D, Panda D. Mechanism of anti-cancer activity of benomyl loaded nanoparticles in multidrug resistant cancer cells. J Biomed Nanotechnol 2015;11:877-889. doi:10.1166/jbn.2015.1998. (Q2, IF.4.1)
Patents:
Filed: Biodegradable three dimentional scaffolds to grow cells in serum deprived condition, Patent application no. 202141033609. Google Scholar: https://scholar.google.com/citations?user=ixAqu2MAAAAJ&hl=en
ResearchGATE: https://www.researchgate.net/profile/Sudarshan_Kini
Orcid Id: 0000-0001-5253-9938
Scopus Id: 53866809000
Researcher Id: R-6434-2019
Principal Investigator
- A novel rapid sensitive fluorescent resonance energy transfer technique for selective detection and quantification of methicillin resistant Staphylococcus aureus, funded by DST-SERB-Early Career Research, 2019-2021 [Budget: Rs. 36,13,764/-]
- Development and characterization of a novel three-dimensional biofilm of Pseudomonas aeruginosa for the assessment of the mechanism of nonmucoid to mucoid strain conversion, virulence, antibiotic resistance and macrophage immune response, funded by ICMR-Adhoc, 2022-2024 [Budget: Rs. 32,53,395]
Co-investigator
- Nano-formulation of lutein to improve bioavailability in prevention of Age-Related Macular Degeneration, funded by ICMR, 2019-2021 [Budget: Rs. 24,27,752/-]
- Investigating the antimicrobial efficacy of NANOBIOTICS against multidrug resistant gut pathogens, funded by DHR-ICMR, 2021-2023 [Budget: Rs. 47,40,247]
- Development of immunofluorescent nanodiagnostic assay as a point-of-care detection of dengue virus, funded by DSt/TDT, 2021-2022 [Budget: Rs. 22,60,224]
- Elucidation of platelet activation and NLRP3 inflammasome response in platelets during invasive Vibrio vulnificus infection to understand its potential role in the immunopathogenesis, funded by ICMR, 2022-2024 [Budget: Rs. 22,62,395]
Dr. AKSHATH U. S
- DesignationScientist Grade-II
- Email akshath.uchangi@nitte.edu.in
- Contact No..
Dr. Akshath completed his Ph.D. at CSIR-CFTRI, Mysore, with a specialization in Biosensors and Bio-imaging. His work was focused on nanoparticle-based biosensors to detect food contaminants and toxins using enzymes/aptamers as biorecognition elements. After his Ph.D., he was awarded the prestigious Marie Skłodowska-Curie fellowship (MCIFs) at the University of Leeds, UK. His work was focused on polyvalent glycan-nanoparticles to decipher HIV/Ebola infections using dendritic cell receptors-DCSIGN/R. His research at NUCSER is focused on developing nano-sensors to detect contaminants, bacteria, viruses etc. His research also focuses on glycan-nanoparticles to decipher bacterial/viral infections and inhibition. He has published papers in journals of international repute ex-Journal of American Chemical Society, Biosensors & Bioelectronics, etc.
- Doctor of Philosophy (Life Sciences), CSIR-Central Food Technological Research Institute, Mysore-2018 (Specialization-Nanobiotechnology)
- Master of Science (Biochemistry), University of Mysore, 2008
- Project assistant, CSIR-CFTRI-2010-2014-NPMASS-DRDO Funded project
- PhD-2014-2018, CSIR-CFTRI Mysore
- Marie-Curie Fellow, School of Chemistry, University of Leeds, UK-2018-2020
No. of PhDs
Ongoing: 2
No. of UGs guided: 4
No. of PGs guided:
Ongoing as guide:3
- Marie-Curie Individual Fellowship-17/18-University of Leeds, UK
- European Commission-Marie-Curie Fellow (Awarded MC-Individual Fellowship 17/18) School of Chemistry, University of Leeds, UK
- CSIR-CFTRI Annual award-2017 & 2018 for best paper published in Applied Sciences- Biosensors and Bioelectronics, 85 (2016): 240-246, Biosensors & Bioelectronics, 100, 15 February 2018, 201-207
- Honored by Karnataka State Govt on 59th Independence Day on the eve of Designing new methods for Paddy cultivation-2005.
- Best oral presentation award for the presentation titled "Deciphering virus-host interactions using polyvalent glyco-nanoparticles" at the 62nd Annual International Conference of AMI held at University of Mysore, Mysore
- Member, Consumable committee, NUCSER
- Member, Vigilance committee, NUCSER
- Member, Royal Society of Chemistry
Undergraduate-
Biochemistry
Postgraduate-
Bio-physical principles and Bio-analytical Techniques, Biochemistry
- Budhadev, D., Poole, E., Nehlmeier, I., Liu, Y., Hooper, J., Kalverda, E., Akshath, U.S., Hondow, N., Turnbull, W.B., Pohlmann, S. and Guo, Y., 2020. Glycan-Gold Nanoparticles as Multifunctional Probes for Multivalent Lectin-Carbohydrate Binding: Implications for Blocking Virus Infection and Nanoparticle Assembly. J. Am. Chem. Soc. 2020, 142, 42, 18022-18034
- Wang, Weili; Kong, Yifei; Jiang, Jun; Tian, Xin; Li, Shuang; Akshath, Uchangi; Tiede, Christian; Hondow, Nicole; Yu, Anchi; Guo, Yuan; Zhou, Dejian, Nanoscale, 2020. Photon induced quantum yield regeneration of cap-exchanged CdSe/CdS quantum rod for ratiometric biosensing and cellular imaging. Nanoscale, 2020, 12, 8647-8655, NC-1
- Sharma, R., Akshath, U.S., Bhatt, P., & Raghavarao, K. S. M. S. (2019). Fluorescent aptaswitch for chloramphenicol detection-Quantification enabled by immobilization of aptamer. Sensors and Actuators B: Chemical, 1 July 2019, 290, 110-117, NC-1
- Akshath, U.S., and Praveena Bhatt., (2017). Supramolecular nano-sniffers for ultrasensitive detection of formaldehyde. Biosensors & Bioelectronics, 100, 15 February 2018, 201-207, NC-2
- Akshath, U.S., and Praveena Bhatt. (2016) Gold nanoparticle synthesis coupled to fluorescence turn-on for sensitive detection of formaldehyde using formaldehyde dehydrogenase"- RSC Advances, 6(60), pp.54777-54784-NC-5
- Akshath, U.S., and Praveena Bhatt. (2016). Tunneling of redox enzymes to design nano-probes for monitoring NAD+ dependent bio-catalytic activity. Biosensors and Bioelectronics, 85 (2016): 240-246, NC-9
- Akshath, U.S., Shubha, L. R., Bhatt, P., & Thakur, M. S. (2014). Quantum dots as optical labels for ultrasensitive detection of polyphenols. Biosensors and Bioelectronics, 57, 317-323-NC-30
- Akshath, U.S., Vinayaka, A. C., & Thakur, M. S. (2012). Quantum dots as nano plug-in's for efficient NADH resonance energy routing. Biosensors and Bioelectronics, 38(1), 411-415-NC-15
Conference publications-09
Conference/Journal publications
Selected Journal publications:
- Budhadev, D., Poole, E., Nehlmeier, I., Liu, Y., Hooper, J., Kalverda, E., Akshath, U.S., Hondow, N., Turnbull, W.B., Pohlmann, S. and Guo, Y., 2020. Glycan-Gold Nanoparticles as Multifunctional Probes for Multivalent Lectin-Carbohydrate Binding: Implications for Blocking Virus Infection and Nanoparticle Assembly. J. Am. Chem. Soc. 2020, 142, 42, 18022-18034
- Wang, Weili; Kong, Yifei; Jiang, Jun; Tian, Xin; Li, Shuang; Akshath, Uchangi; Tiede, Christian; Hondow, Nicole; Yu, Anchi; Guo, Yuan; Zhou, Dejian, Nanoscale, 2020. Photon induced quantum yield regeneration of cap-exchanged CdSe/CdS quantum rod for ratiometric biosensing and cellular imaging. Nanoscale, 2020, 12, 8647-8655
- Sharma, R., Akshath, U. S., Bhatt, P., & Raghavarao, K. S. M. S. (2019). Fluorescent aptaswitch for chloramphenicol detection-Quantification enabled by immobilization of aptamer. Sensors and Actuators B: Chemical, 1 July 2019, 290, 110-117
- Akshath, U. S., and Praveena Bhatt., (2017). Supramolecular nano-sniffers for ultrasensitive detection of formaldehyde. Biosensors & Bioelectronics, 100, 15 February 2018, 201-207
- Akshath, U. S., and Praveena Bhatt. (2016) Gold nanoparticle synthesis coupled to fluorescence turn-on for sensitive detection of formaldehyde using formaldehyde dehydrogenase"- RSC Advances, 6(60), pp.54777-54784
- Akshath, U. S., and Praveena Bhatt. (2016). Tunneling of redox enzymes to design nano-probes for monitoring NAD+ dependent bio-catalytic activity. Biosensors and Bioelectronics, 85 (2016): 240-246
- Akshath, U. S., Shubha, L. R., Bhatt, P., & Thakur, M. S. (2014). Quantum dots as optical labels for ultrasensitive detection of polyphenols. Biosensors and Bioelectronics,57,317-323
- Akshath, U. S., Vinayaka, A. C., & Thakur, M. S. (2012). Quantum dots as nano plug-in's for efficient NADH resonance energy routing. Biosensors and Bioelectronics,38(1),411-415
Patents
• A Colorimetric Reagent Kit for the detection of formaldehyde CSIR-CFTRI, Patent application number- 202211019411
All publication:
https://scholar.google.com/citations?user=-f785t4AAAAJ&hl=en&oi=ao
Conference/Journal workshops: 09
- Polyvalent multifunctional core-shell satellites for ultrasensitive detection of target nucleic acids-a multiplexed approach-2021-2024, Funded by UGC-Faculty research promotion scheme, Start-up-Grant, Budget ₹10,00,000/-
- Target-induced Core-shell satellite structures: Creating a polyvalent multifunctional platform for multiplexed detection of nucleic acids, DST-SERB-SRG/2021/000202, 2021-2023, ₹32,70,340/-
- Development of a paper-based point-of-care biosensor for detection of heavy metal poisoning, ICMR, 2022-18279/F2, 2023-2026, ₹35,48,395/-
- Polyvalent multifunctional core-shell satellites for ultrasensitive detection of target nucleic acids-a multiplexed approach NUFR1 - Nitte University Faculty Start-up Research Grant, 2021-2023, Budget ₹1,50,000/-
- Fluorescent disease sniffers, doi:10.1038/nindia.2012.121; Published online 23 August 2012, Nature India
- Optical sensor to detect dietary polyphenols, doi:10.1038/nindia.2014.49; Published online 16 April 2014, Nature India
